There is a technical service bulletin for the V8 engines regarding a possible problem with the spark plug being ejected from the cylinder head, damaging the threads in the spark plug hole. If the vehicle is under warranty, cylinder head replacement is recommended. If the vehicle is out of warranty, Ford authorized the use of a specific thread insert to repair the head.
Problems for specific Ford F-250 Super Duty years:
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Most reported 2000 Ford F-250 Super Duty problems
Using the correct oil for this engine is critical. Improper engine oil can foam in the high pressure system and not develop enough pressure for operation. Symptoms of this can be hard starting, long cranking time before start, rough engine idle, and a lack of power. Another sign is tiny bubbles in the oil on the engine oil dipstick after the engine is shut off. The additives in the correct oil that protect against foaming can still break down, so changing the oil at the correct intervals is important.