There is a technical service bulletin for the V8 engines regarding a possible problem with the spark plug being ejected from the cylinder head, damaging the threads in the spark plug hole. If the vehicle is under warranty, cylinder head replacement is recommended. If the vehicle is out of warranty, Ford authorized the use of a specific thread insert to repair the head.
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Most reported 1998 Ford F-250 problems
The EGR orifices in the intake manifold may plug with sludge. If the truck has high mileage, this may cause engine misfire when first accelerating because too much EGR gas is directed into the cylinders of the unplugged orifices. This makes the mixture lean, which causes a gradual stumble that increases in severity until repaired.