During production, on fifty-four Mercedes S-Class models, the front and rear door locks may have been mistakenly interchanged. This means that a rear passenger could open the rear door with a simple pull of the interior door handle, and the front passenger could not open by pulling on the interior handle. This situation could affect the safe exiting of the vehicle in a crash or protection against the accidental opening of the rear door by a child. Dealers will inspect the part numbers on all door locks and replace any that are incorrect. The recall began on March 27, 2009. The Mercedes-Benz recall number is 2009030001.

Due to a manufacturing defect, a crack can develop on the fuel filter when the vehicle is operated in high temperatures. This crack can result in a fuel leak, increasing the risk of a fire. Dealers will replace the fuel filter to correct this concern.