The alternator may fail causing the battery to go dead. The charge light on the dash may or may not illuminate. The alternator may also develop an abnormal noise. A failed alternator will require replacement.
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Most reported 1995 GMC Vandura 2500 problems
The intake manifold gasket may develop and external engine oil or coolant leak. In some cases, an internal coolant leak may occur causing coolant to mix with the engine oil. Running the engine with a coolant/oil mix may result in engine damage. Replacing the intake manifold gasket should correct this issue.
An engine vacuum leak may develop from the throttle body gasket causing a higher than normal idle speed. Failed gaskets should be replaced.
A coolant leak may develop from the water pump. This can result in an engine overheating condition. A leaking water pump will require replacement.