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Q: Misfire on 1999 GMC Yukon

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Had a check engine light come on this weekend both times were when I was accelerating up a steep mountain pass. The light would come on and then flash throughout acceleration. Eventually just staying on. The code said it was a Cylinder #4 misfire. Don't remember the code number though. This is the first time this has coded this code. Just recently replaced an o2 sensor that was coding Bank #2 Sensor #2. Any relation? And should I start with the plug or is this something bigger?
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