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2010 Mercedes-Benz E550 4MATIC Questions

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Is it dangerous to drive when you have an output bearing (in transmission, making noise) that will need to be replaced in the future. Ready to take a trip and not sure what to do.
Just came on this morning. Manuel says fuel line related or catalytic converter. Have lots of driving to do and shop can;t get me in for over a week. Safe to drive without harming the engine?
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