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Q: could the rear differential cause a a tire to completely FALL OFF while driving? on 1998 Chevrolet Suburban 1500

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We were driving down highway and started to feel the back end of the truck start to shake. Then it started to feel like we had a flat tire. We were less than a 1/4 mile away from the gas station when the tire JUST SHOT OFF THE TRUCK!(went flying deep into the woods). We then slid across the road about the length of a football field. Luckily we did not flip and there were no other cars around us at the time. could this be caused by the rear differential or is there a bigger issue we over looked? Please help someone!!
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Sounds like someone did not torque the lug nuts properly. Unless the axle shaft came out with the wheel, in that case then it is a diff. problem!
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