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Q: Check Engine light; loss of engine power even with throttle pressure, mis-fire on 2003 Ford F-250 Super Duty

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All at about the same time my check engine came on and my truck began to lose power and mis-fire and when I pressed heavily on the throttle the truck would not respond or took some time to respond to the throttle pressure. I have 195K miles on my 2003 F-250 Super-Duty 7.3L V8 Diesel Turbo;what could cause this to happen?
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