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Q:

will a dirty air filter affect the ac? on 2000 Toyota Sienna

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doesnt cool properly
(2) Answers
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A restricted "Cabin Air Filter/Pollen Filter" would definitely affect the ventilation inside the passenger compartment if that's what you had been told or heard but the 2000 Sienna does not have provision for a cabin air filter.
No, a dirty air filter will not cause the A/C system to operate inefficently. Pressure readings will have to be performed to determine if the root cause of the A/C system issue. I suspect it may be low on refrigerant from a small leak.