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Replace thermostat, water pump. At 50,000 miles had service of manifold done at a cost of 1200 by Buick dealer
Overheating can be caused also by a malfunctioning cooling fan, an air flow issue through the radiator, and even an air pocket in the cooling system following thermostat and water pump repairs.
Q&A > Buick > 2006 Buick Rendezvous