Locks do not work using either the door switches or the key fob. Only manually.
Why have auto/door locks stopped working? on 2005 Chrysler Town & Country
try another key fob to start with then ck pwr source
I would start by verifying power to the circut is good, the fuse, etc. Also the ground. Sometimes the wiring that passes thru to the driver's door breaks where it flexes. This can disable the entire system.