Why do I keep blowing main battery fuses? on 2005 Chevrolet Uplander

I have a 2005 Chevrolet Uplander 4WD. In the past week I needed a new battery. Then all of the sudden, it seems like everything stopped working like a domino affect. My turn lights went out, no power locks, doors or windows. The power seat also stopped working. I looked at the fuses underneath the hood and noted that 3 fuses were blown. They were the main battery 2 and 3 both 60 AMP fuses. Also was the . Also blown was the front blower HI 40 AMP fuse. The fuses were replaced and the vehicle was running great with all components working properly. Then a few hours later as I was driving, all three fuses were blown. Can anyone tell me what the problem could be? I would appreciate any and all input.

Asked by for the 2005 Chevrolet Uplander
A short circuit is blowing fuses. Best to check to see if when battey was replaced if and wires could be moved from where they were. You could have serious damage to on board systems if not taken care of asap.