vehicle cranks but no start, what to look for first on 2005 Dodge Durango

4.7 engine , auto, 4x4, over 100,000, no syptems or previos problems

2 answers
Check the fuel pump for proper function and current to pump. Then check fuel filter and then check for spark at plugs. Good luck and let us know how it goes. Do you have any check engine lights on? If so, post the codes on here.
I agree with #1