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Ase Master 2001
Sounds like you may have lost a ground... check fuses and wiring where possible, otherwise it will need to be diagnosed by a technician.
Selector control switch could have failed, you would want to have it checked out...
Keep eye out for check engine light.. could be the beginning of shift solenoid issue. Check for proper fluid level and condition asap.
I would agree with previous answer, but also test for possible failure of the Ignition module... This would attribute to a spark or ignition condition supported by the starting fluid failing to start the engine. ICM's or ignition control module's are common to fail when hot and will work when cooled. 4.3L also have a common issue relating to the coolant temp sensor, when they heat up they can have voltage issues causing the PCM send false commands to fuel system. I've seen engines get overload of fuel, causing massive flooding and also seen them cause a no fuel issue. Smell for excessive gas smells during a no run condition. Or next time it acts up you can unplug the Coolant Temp Sensor to see if it changes. May cause a DTC or Check Engine Light, but this may be cleared by unhooking ground on battery for a few min in the year of your truck.
Does the engine temp increase when driving? Could have water pump impeller issue thus not properly circulating the coolant.... If engine temp lowers while driving you may be missing the thermostat causing the coolant (antifreeze) to cool to quickly. Although it could be a number of other possibilities or combinations. I'm local if you have any further questions.