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I would !
The under engine cover has to be removed to access the engine and drain plug.
Make sure the radiator cooling fan is working.
Are you getting fuel pressure, is the pump running. The relay I believe is not accessable on year models close to that. Have had to wire a new relay into those that are incorporated into the module.
Have never seen one on those models.
It's probably caused do to a misfire, possible plug, coil, or intake is all possible. Not sure which sensor is being referred to. Have it scanned for more information.
If it's an obvious leak, it can't hurt. If the code comes back they should look further.
Possible bad connection in the computer data line, could be an easy fix, have it tested.
More then likely the driver's side blend door actuator.
It must be someone with the Honda software to be able to program the Honda.