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Take doorPanel off to access window regulator moter. Unplug the Motor use a test light probe one can be bought at any auto parts store. ground the probe gator clip and check each prong on the plug. operate the window switch and check each plug prong. You should get a light when you push the UP on the window switch and when you push Down on the switch you should also get a light indication with your Tester. No light on the tester means you have a possible blown fuse. If UP and DOWN tester lights that means you have power to the MOTOR and the Motor is either locked up or simply BAD. Good Luck
The Low pressure line will have a plastic cap with the letter L on the cap which you will unscrew. probably back toward the left rear next to firewall.
You need to try an engine treatment / injector cleaner called SEA FOAM one can per Tank Fill up every other tank fill up. If you are driving very short distances and your Catalytic Converter never gets to its Maximum Heat up Range this is bad for the Catalytic Converter because it has to be able to fully heat up to burn the exhaust gasses. It will tend to clog up if it doesn't ever get to full Heat Up and Clean itself. The Sea Foam will help also so give it a try. Good Luck
A reputable mechanic can test the radiator fluid to see if you have a cracked engine head or a leaking Head gasget. Probably Oil in your Antifreeze causing it to be black. Sorry but it sounds like you have some major repairs that need to be done ASAP.
You will definately need to remove the Door Panel to get to the mechanics of the Door Lock mechanism. Door panels are very Tricky and have a certain way to be removed. Do not attempt to remove it if you have never done this because you could damage critical parts of the panel. You should find knowleageable technicians at a Auto Glass shop they are used to removing door panels. Good Luck
You probably have a front or Rear enging seal leaking. Check where you Park and see if there is oil residue. If no leakage detected you may have a Valve Seal defective. Have someone check your Spark Plugs to see which one may be fouling out because of oil seapage. This will narrow the search on the leaky valve seal.
absolutely do not replace plugs or the Timing belt. Wait until around 110,000 miles before you replace plugs or timing belt. Your local mechanic will be able to tell you exactly when you should change your plugs and timing belt. The Lexus is a well engineered car and you should expect flawless performance for many years. You need to be using a Fuel Additive preferably SEA FOAM engine/injector cleaner at least one Can every 3rd fill up just add one can to your Tank during fill Up. You will notice your car performance to improve along with your fuel economy. Also check your air filter regularly and keep it blown out with an Air Hose, it is not necessary to replace it with every Oil change. You can also upgrade your air filter with a K & N oiled air filter this will improve Air Flow and increase your MPG
Your Cam should be fine. If your front and Rear seals are not showing any signs of leakeage they are also fine. Sounds like you have a good mechanic because some mechanics would possibly take advantage of the situation and change them out to just make more money.
O2 Censors do go out ocasionally. I had that problem also I ended up replacing my Catalytic Converter because it was getting clogged and not burning off the exhaust gasses like it should. Catalytic Converter will sometimes foul out the O2 Censors. If I were you I would buy 4 cans of SEA FOAM engine treatment and pour one can per tankfull. drive it for a Month and see if that solves your problem. If you don't have time to drive it for a month just you may need to replace your Catalytic Converter with a new one. If You have been filling up with regular fuel for years and you have never used an engine treatment like Sea Foam that is probably why your Converter is getting clogged. If you only drive short trips to work or wherever you go the converter does not have time to Heat Up this diminishes the life of the Catalytic Converter. The Converter needs to be able to Heat Up to it's Maximum to be able to clean itself out and burn Up the exhaust fumes so that you can pass emessions test. Try driving your Car for about 30 to 40 miles before you drive up for your emissions test also use the SEA Foam treatment in your Tank of Gas. Leave your Car running while you are in line for your Emissions Test don't kill it and allow it to get cold. Wait until the weather gets warm like in the summer time this may help your converter to get to it's Maximum Heat range. Good Luck
If it's OE sunroof search your local salvage yards and if that fails get online and search salvage yards. This will be your cheapest route. Dealership will want a small fortune for a replacement. If you do have to go to a dealership give them your VIN No. they will be able to look up the exact part for your car.