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transmission problem? on 2006 Ford Expedition

My 2006 expedition, 60K miles, hesitates or falters when I ease off the gas (even slightly) at highway speeds. The problem is intermittent but gets much worse after I have been driving over an hour. The vehicle is fairly well maintained; regular oil changes and fluid levels checked. Any ideas?

Asked by for the 2006 Ford Expedition
Start with checking for diagnostic trouble codes in the PCM. If the spark plugs have never been changed, I would recommend replacing them. Check for vacuum leaks.