Models with electric sliding doors can develop problems with the door mechanism. The cable in the door becomes frayed, which will damage the electric motor.
2010 Toyota Sienna Problem Reports
Most Reported 2010 Toyota Sienna Problem Reports
Transmission cover busted open at top while I was driving down a busy road. Pieces started falling out. I made it to side of road and transmission fluid completed drained and gears seized. Transmission had to be replaced (with rebuilt transmission).