Models with electric sliding doors can develop problems with the door mechanism. The cable in the door becomes frayed, which will damage the electric motor.
Problems for specific Toyota Sienna years:
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Most reported 2010 Toyota Sienna problems
Transmission cover busted open at top while I was driving down a busy road. Pieces started falling out. I made it to side of road and transmission fluid completed drained and gears seized. Transmission had to be replaced (with rebuilt transmission).