On higher mileage vehicles, an engine misfire may develop and/or the Check Engine Light may illuminate due to a failed ignition coil. It is not uncommon to replace all the coils when the first one fails in order to prevent return trips to the repair shop.
Problems for specific Toyota Highlander years:
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Newest reported 2008 Toyota Highlander problems
A problematic center airbag sensor can cause the airbag malfunction light to illuminate.