Irregular and premature tire wear can be caused by the front thrust link bushings cracking and causing excessive movement in the suspension. The thrust link bushings are fluid-filled (to help reduce vibration), so if they crack, they will leak oil.
Car Problem Reports
Mercedes-Benz E350 Tire Wear Caused By Worn Front Thrust Link Bushings
Mercedes-Benz E350 Problem
Average Mileage: 59,500 mi (28,000 mi - 80,000 mi)
Visitor, 2007 Mercedes-Benz E350, 70,000 mi
Tires prematurely wear out at 10k miles due to axle sagging. MB dealership stated this is a known problem with the E350 2007 model through 2010 models. Weight of the engine causes axle to "sag" over time, not necessarily miles and "bolts" had to be installed to "strengthen" the axle.
Visitor, 2007 Mercedes-Benz E350, 79,000 mi
Tires installed at MB dealership in December 2011. November 2012, tires have only 14,000 miles and the inner side of the tires are worn out. Had to have car alignment and 3 bolts installed in order for the front end to be aligned. Close to $300 for repair. Dealership stated this is a problem with the E350 models due to the weight of the engine on the axle. After a few years, the axle parts begin to spread causing the tires to eat from the inside.
Visitor, 2007 Mercedes-Benz E350, 65,000 mi
Experience "clunking" at low speeds and "bang" noise when turning tight corners. Both Lower Thrust Control Arms replaced (due to either bad bushing and or ball joint's attached)
Visitor, 2007 Mercedes-Benz E350, 80,000 mi
Visitor, 2008 Mercedes-Benz E350, 28,000 mi
Had to replace front tires,totally worn on the inside edge indicating severe negative camber