2000 Mercedes-Benz E320 4MATIC Q&A

2000 Mercedes-Benz E320 4MATIC Question: The car will be running correctly and suddenly will not accelerate.

I can be on the street or freeway and suddenly I can't accelerate even if I have the pedal all the way to the floor. This has happened twice in one day, it's sporadic and if I turn off the car for a while it's fine for a bit then suddenly it occurs again. Is it the engine or transmission -
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