The bushings for the shifter lever wear out to the point where they break and fall out. This causes excessive movement (loose feel) in the shifter lever and a clanging-type noise when changing gears.
Car Problem Reports
Mercedes-Benz C220 Shifter Lever Bushings May Break Causing Loose Feel/Noise
Mercedes-Benz C220 Problem
Average Mileage: 95,333 mi (38,000 mi - 148,000 mi)