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Q:

Runs very smooth until I reach 65mph then front end & steering wheel shake on 2000 Ford Explorer

Rookie cbe0621eac06868b3efe0d8d1d3611e23c60d3114864ea2ec19a68cfbd3eebab
It's a 2wd Sport. Ran great until I let my brother use it to run errands. Noticed the shaking and vibrating the next night. No codes come up. Tires are properly inflated.
(1) Answer
Check for bent rim or bad shock , or loose steering components. Maybe a pothole was hit and he wasn't aware of the severity of it.