Rough Running Engine and Possible Check Engine Light on Ford E-150

The Check Engine Light may illuminate, the engine may run rough and have misfires on acceleration. Commonly the ignition coils and/or the ignition coil boots are the cause of this problem. The rubber boot that insulates the coil to the spark plug can dry and crack allowing arcing. Inspect the coils and boots, and replace them as needed. Our technicians also recommend replacing the coil boots any time the spark plugs are replaced.

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Average mileage: 133,066 (41,000–245,000)
Engines affected: 4.2L V6, 4.6L V8, 5.4L V8
14 model years affected: 1997, 1998, 1999, 2000, more2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010
63 people reported this problem
16 people shared problem details
2000 Ford E-150- 5.4L V8150,145
driving down the road the check engine light starts flashing and the front end starts shaking then it stops for a while and does it again real sulgish during this time
2003 Ford E-150- 4.6L V865,000
the motor started missing lightly at first and real bad later. after scanning it was found to have a bad coil #7 cylinder i believe. I replaced the coil and problem was solved,but only for about three weeks, and it started all over again. I replaced the coil again and problem solved for about three weeks again. This missing is usually bad with acceleration. can the coil boot be the problem,and if so why does it not miss for about three weeks.
2002 Ford E-150- 5.4L V8145,000
Engine stumbles going uphill at times, hesitates at other times on flat road. Hesitates on acceleration from stop. Got "#5 cylinder misfiring" diagnostic message. Ran great for 2 days, then same problems.
2002 Ford E-150- 5.4L V8150,000
engine runs rough and misfires... changed plugs, fuel pump, cleaned and checked egr. changed o2 sensors, problem still persists
2000 Ford E-150- 4.2L V6214,000
Rough running engine and pinging as if the timing has changed. The check engine light blinks.
2000 Ford E-150- 4.6L V882,000
replaced only select coils. Vehicle is doing better but still running rough when it goes uphill or putting a load on it.
2001 Ford E-150- 4.2L V6120,000
It was shaking and rough while driving and engine light came on flashing then went away
2005 Ford E-150- 4.6L V864,000
Had same problems over about a 6 week time frame. After replacing coil wires, boots, a fuel pump, and spark plugs the dealer finally sent data to Ford. Within an hour Ford diagnosed a wiring harness problem. Wiring harness was against manifold causing intermittent shorts. Spent over $2,000 for a $100 fix. But vehicle runs fine now
1997 Ford E-150- 4.6L V8170,000
Truck was miss firing, running like crap, cel was flashing when I accelerated. I cleaned my mass air flow system out, cleaned the throttle body out and im about to check the code tomorrow.
2003 Ford E-150- 4.2L V694,000
low conpression on #2 cylinder running lean new plugs, wires, coil, checked out by garage.
1997 Ford E-150- 4.6L V8200,000
Run rough until get to2000 rmp
1999 Ford E-150- 4.2L V6
heater core line n front of motor metal line is cracked
2000 Ford E-150- 4.2L V6
i have the same issue i have replaced the fuel pump and it seemed to run good and now its back to running rough again
2003 Ford E-150- 5.4L V8140,000
Ignition coils
Same problem.
1998 Ford E-150- 4.2L V6156,000
engine idle was rough, and cel was flashing
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