How hard is it to replace the radiator in my truck and is it a job for a weekend mechanic. I could save about 500 bucks doing it myself if it doesn't require anything too elaborate.
Radiator Replacement on 2004 Ford F-250 Super Duty
Here is a link for the repair information for your Ford, this should help. I would look this information over. If you have time, like all day Saturday, so you can be really careful , then it is possible to do. I looked over the procedures and it isn't too complex. Get a factory quality radiator, from a very reliable parts store.
even though the book pays around 3-4 hours, it will probably take you double since you do not do it all the time. be very carefull and watch what you take apart.