A thumping heard and felt in the floor is often caused by failing engine mounts. A failing mount allows too much movement of the engine, and will require replacement.
Problems for specific Nissan Quest years:
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Most reported Nissan Quest problems
The distributor shaft bearing can become rusty, and seize causing the engine to stall or not start. The failed distributor will commonly require replacement.
The exhaust manifold often warps and cracks, breaking off the studs between the cylinder head and the exhaust manifold. The noise may be most noticeable when the engine is cold.
A creaking or clicking heard while the vehicle is accelerating can be caused by dirt and corrosion build up between the splines of the front hubs and CV axle shafts. Removing, cleaning, and applying a light coat of grease on the axle shaft splines will commonly correct this concern.
A coolant leak may develop from a plug on the front of the rear cylinder head, behind the timing cover.
Our repair shop has recently had issue with 04 quest burning out ign coils after 2 days of driving with replacement of all 6 coils. Thought we had defective coils so we replaced again, 2 days later same problem. Found ground cable from battery was completely broken off where it mounts to the transmission under the battery tray, resulting the eng to ground through the coil grounds burning them out. Replacing rear three coils 3 times was a treme...