The engine may develop a stalling and/or no start condition due to a failed crankshaft position sensor.
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Repairpal verified Mercedes-Benz S550 problems
The camshaft adjuster solenoid (which is related to the variable valve timing system) may fail or timing chain/balance shaft components may wear, resulting in illumination of the Check Engine Light and various drivability issues. Mercedes-Benz has released a service bulletin outlining specific repair instructions depending on fault codes stored.
A vibration felt through the center floor of the vehicle can be caused by driveshaft flex discs, which crack and shred, causing excessive driveshaft movement. Not repairing these can cause damage to the driveshaft center support bearing, or, in the worst case scenario, damage to the transmission or differential.