The early versions of the central gateway module (which allows different systems to communicate with each other) have software problems.
Problems for specific Mercedes-Benz E320 years:
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Most reported Mercedes-Benz E320 problems
Lack of audio or cell phone functionality may be related to the failure of the audio gateway module.
Many software updates are available for the different computer systems, but if the vehicle is out of warranty, it may cost money to receive the updates (unless it is a recall). Some updates may be dealer-only, but a well-equipped independent shop can usually provide updates as well.
Fuel leaks, erratic or rough engine operation, and fuel economy issues can be caused by the failure of a fuel system component called the EHA (electro-hydraulic actuator) valve.
This vehicle has sensotronic brake control (SBC). If the SBC light on the dash illuminates, have the brakes checked. If the SBC is not working, limited brake pressure is delivered to the front brakes, increasing the distance it takes to stop. The SBC hydraulic unit has a specific service life programmed into the control module; follow the manufacturer's recommended service procedure for proper maintenance of the SBC.
Due to age and sun exposure, the interior wood trim cracks and the finish gets a cloudy haze. Replacement if the trim would be the most common solution to the problem.
The electronic throttle assembly may suffer an electrical failure. It is often cheaper to send the valve to a service center for repair that to purchase a new part.
Irregular and premature tire wear can be caused by the front thrust link bushings cracking and causing excessive movement in the suspension. The thrust link bushings are fluid-filled (to help reduce vibration), so if they crack, they will leak oil.
One or more of the following steering linkage components may wear prematurely; tie rod ends, drag link, or idler arm. Our technicians remind us the wheel alignment should be checked and adjusted if any of these items are replaced.
Due to wear of the internal drive gear, the speedometer can stop working.
The check engine light illuminated. An OBD reader confirmed a problem with the Secondary Air Injection System. I also noticed a loud roaring type noise for the first two minutes after vehicle starting. The problem was traced to a failed Secondary Air Injection Air Pump. Dealer wanted $1,300 to replace. I sourced a Bosch pump for the application and replaced it myself for around $450.