The evaporator temperature sensor can fail, causing the AC compressor not to cycle. If the AC compressor does not turn on, the AC system will not blow cold air. If the compressor is stuck on, the air will be very cold at first, before warming up.
Problems for specific Mercedes-Benz E320 years:
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Most reported Mercedes-Benz E320 problems
Cup holders break easily, especially if sticky liquids are spilled into the cup holder mechanism.
The third (high) brake light housing may melt, resulting in a loss of electrical contact for the light, which stops working. A complete housing (contacts and lens) is needed to repair the problem. On certain vehicles, if this happens, the anti-lock brake system will not function. The brakes will work in normal mode, but not provide the ABS control.
A vibration felt through the center floor of the vehicle can be caused by cracked and/or shredded driveshaft flex discs, resulting in excessive driveshaft movement. If not repaired, damage to the driveshaft center support bearing, transmission, or differential can occur.
The release tab for the center console can fall off unexpectedly.
Irregular and premature tire wear can be caused by the lower control arm bushings cracking, resulting excessive movement at the control arm pivot point. Ball joints can also wear out prematurely, causing similar tire wear symptoms. I some cases it may be necessary to replace the lower control arm, including bushings & ball joint to correct this concern.
PSE system, voice control module, or Tele Aid module failure can cause a lack of audio. These same modules can also cause dead battery conditions when they fail to "time out." Many electronic control modules are active even when the engine is off. If these modules stay active, they will drain the battery, which is why they have a timer built into the modules. The timer shuts down the modules after a preset amount of time (timing out). If a module does not time out, it will stay active and drain the battery.
An engine Oil leak may develop from the PCV vent housing on the valve cover and/or the inspection plate on the front of the engine.
Water can damage the weight sensor in the front, passenger seat, causing the SRS (airbag) light to illuminate. There is an electrical component in the seat cushion susceptible to fluid damage. Any spills should be dried up immediately in order to try and prevent damage to the sensor.
The engine wiring can degrade because the insulating material falls off leaving the bare wire exposed. This can cause many problems depending on which wires are exposed and what they touch.
The ESP and BAS warning lights may illuminate due to a failed brake light switch. Replacement of the failed switch should correct this concern.
The switch for the vanity mirror light above the sun visor fail; there is an updated switch for some models. On the remaining models, due to a redesign, the mirror "cassette" will need replacement.
The rubber bond in the harmonic balancer can decay, which causes the balancer to move and work its way toward the timing cover. If the balancer comes into contact with the timing cover while the engine is running, it will fracture and damage the cover and potentially other surrounding parts. The harmonic balancer should be inspected at every service.