There have been reports of various transmission problems with this model.
Problems for specific Honda Odyssey years:
Car problem reports
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Most reported Honda Odyssey problems
A chirp noise from the timing belt area can be caused by a tilted idler pulley. Installing a corrective shim from Honda will commonly correct this issue.
Rear vent windows not operating properly is a common problem with Honda Odesseys. The solution is to replace the window motors.
The AC evaporator drain can clog and cause a water leak inside the vehicle, usually on the passenger floor. Cleaning the drain will fix this problem.
A faulty gasket can cause coolant seepage from the water passage near the exhaust gas recirculation (EGR) valve. Replacing the gasket should correct this coolant leak.
Third row seat latch cables can come loose from the handle and can prevent the seat from unlatching. Reinstalling the cables and retaining them with clips should correct this issue.
On some models faulty front wheel bearings can cause a growling type noise from the front of the vehicle. Replacing both front wheel bearings is recommended for this repair.
A refrigerant leak may develop from the AC evaporator causing the AC to blow warm air. Verifying failure of this component is difficult. A good shop will use leak detection dye to verify a failing evaporator.
On certain models moisture can get into the rear wheel bearing and cause a noise. Replacing the rear wheel bearing is needed for this issue.