Q&A

Can you feel the engine misfire? Any other codes? Which engine is in your S10? Manual or automatic transmission?

As I have learned through trying to figure out my problem, a bad mass air flow sensor can cause misfire codes, sense it regulates and measures the amount of air that passes through, the three main components of a running engine is fire, fuel, and air, to much or too little air can cause all the problems that you have discribed, also the mass air flow sensor is notorious for going out on these engines

i would ck the popit nosil injectors(octo-puss style) thats the number 1 problem i have had with them sense day one

Pull out the trouble code on your vehicle and change whatever parts necessary

i change coil,spark plugs , wires, oil, and oil filter

Many things can cause such an issue, but the one issue that is solely S-10 related is that the earlier-model poppet-style fuel injectors used in the '96-and-up model year Vortec engines were prone to sticking open or sticking shut after a large mileage buildup. Gm was even forced to address the issue in the early '00's by updating the injector style. The new injectors had the same flow rate, but were designed in such a way as to alleviate the problems found in the earlier ones.
There was even a forced recall/replacement in the state of CA due to a lawsuit by the EPA in that state, claiming the poor design was leading to a higher-than-average rate of emissions testing failures in the above-described model years.
This is oftentimes the culprit in the 4.3 engines when all the other standard solutions have been exhausted, ie: spark plugs, wires, cap and rotor, etc..

Read more: http://wiki.answers.com/Q/What_causes_random_misfire_on_1...