no 5 cyl misfires on 2000 Mercedes-Benz E320

should I replace all 6 coils or would the 2 that fire no 5 be enough

Asked by for the 2000 Mercedes-Benz E320
I would test them, just because a couple have failed does not mean the rest will. Test them and fix only what is broken. It would probably be a good idea to replace the spark plugs if they exceed 60,000 in mileage while you have it apart. Ron.
2 more answers
i would only do the ones that you have to
your issue is likely not a coil; the plug wires get soaked with oil from the valve covers. you can buy the plug wires
individually as needed.