The fuel injectors can fail and cause drivability problems. Often there is no Check Engine light and the failures can be caused by corrosion of the connector, clogging beyond the point of cleaning, and/or internal failures.
Problems for specific Nissan Xterra years:
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Newest reported 2004 Nissan Xterra problems
The coolant outlet on the front of the lower intake manifold may develop a coolant leak.