The fuel injectors can fail and cause drivability problems. Often there is no Check Engine light and the failures can be caused by corrosion of the connector, clogging beyond the point of cleaning, and/or internal failures.
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Repairpal verified 2004 Nissan Xterra problems
The coolant outlet on the front of the lower intake manifold may develop a coolant leak.
A whining or buzzing type noise may develop from the timing chain area caused by excess slack in the secondary timing chains. Nissan has issued a service bulletin (NTB09-128) regarding this issue. Replacement of both secondary timing chains and their tensioner shoes will be necessary to repair this concern. As part of this repair, the engine oil and filter should also be replaced.