A thumping heard and felt in the floor is often caused by failing engine mounts. A failing mount allows too much movement of the engine, and will require replacement.
Problems for specific Nissan Quest years:
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Newest reported 2008 Nissan Quest problems
A creaking or clicking heard while the vehicle is accelerating can be caused by dirt and corrosion build up between the splines of the front hubs and CV axle shafts. Removing, cleaning, and applying a light coat of grease on the axle shaft splines will commonly correct this concern.