The EGR valve can become clogged with carbon, which causes the Check Engine Light to illuminate. This can result in moderate to severe misfires on acceleration and the EGR valve and passages will need to be cleaned.
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Repairpal verified 2000 Nissan Frontier problems
A whining or buzzing type noise may develop from the timing chain area caused by excess slack in the secondary timing chains. Nissan has issued a service bulletin (NTB09-128) regarding this issue. Replacement of both secondary timing chains and their tensioner shoes will be necessary to repair this concern. As part of this repair, the engine oil and filter should also be replaced.
The distributor shaft bearing can become rusty, and seize causing the engine to stall or not start. The failed distributor will commonly require replacement.