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Misfire on 1999 GMC Yukon

Had a check engine light come on this weekend both times were when I was accelerating up a steep mountain pass. The light would come on and then flash throughout acceleration. Eventually just staying on. The code said it was a Cylinder #4 misfire. Don't remember the code number though. This is the first time this has coded this code. Just recently replaced an o2 sensor that was coding Bank #2 Sensor #2. Any relation? And should I start with the plug or is this something bigger?

Asked by for the 1999 GMC Yukon
plugs and coil boots or wires should do it code would be p0304 cyl.4 mis detected
1 more answer
no. 3 cylindar misfire with new plugs and wires.