Front thrust arm and control arm bushings can crack and sometimes tear completely. If this is not repaired quickly, damage to the front subframe unit will occur, which is very expensive to repair. Updated control arms (that prevent damage to the subframe when the bushings wear out) are available.
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Repairpal verified 2006 Mercedes-Benz S600 problems
Cup holders break easily, especially if sticky liquids are spilled into the cup holder mechanism.
Due to wear of mechanical parts in the control head, the buttons on temperature control assemblies work erratically or not at all. These control heads need to be replaced for this concern or when the display screen starts to fade out.