One or more door windows may stop working due to a failed window regulator. Replacement of the failed regulator will be necessary to correct this concern.
2000 Mercedes-Benz S500 Problem Reports
RepairPal Verified 2000 Mercedes-Benz S500 Problem Reports
The active body control system can leak fluid from numerous areas, including the tandem pump, hydraulic lines, struts, and/or seals. If it is not repaired, the vehicle ride height could drop too low and cause damage to the undercarriage.
A vibration felt through the center floor of the vehicle can be caused by cracked and/or shredded driveshaft flex discs, resulting in excessive driveshaft movement. If not repaired, damage to the driveshaft center support bearing, transmission, or differential can occur.
The ESP and BAS warning lights may illuminate due to a failed brake light switch. Replacement of the failed switch should correct this concern.
The door for the vanity mirror (or the frame for the door) can break; due to a redesign, the mirror "cassette" will need replacement.