The transmission drive selector module may fail resulting in the loss of gear selection capability. This condition can leave the vehicle stranded, and will require replacement of the drive selector module.
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Repairpal verified 2008 Mercedes-Benz R320 CDI problems
The engine may stall or not start due to a failed crankshaft position sensor. Replacing the failed sensor should correct this issue.
The panoramic sunroof and shade may stop working due to a broken sunshade drive/guide.