The engine wiring can degrade because the insulating material falls off leaving the bare wire exposed. This can cause many problems depending on which wires are exposed and what they touch.
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Newest reported 1995 Mercedes-Benz E300 problems
Due to wear, high usage vehicles can experience ignition lock and tumbler failures. The ignition lock cylinder will generally require replacement to correct this concern.
The bushings for the shifter lever wear out to the point where they break and fall out. This causes excessive movement (loose feel) in the shifter lever and a clanging-type noise when changing gears.
A vibration felt through the center floor of the vehicle can be caused by cracked and/or shredded driveshaft flex discs, resulting in excessive driveshaft movement. If not repaired, damage to the driveshaft center support bearing, transmission, or differential can occur.