On higher mileage vehicles, an engine misfire may develop and/or the Check Engine Light may illuminate due to a failed ignition coil. It is not uncommon to replace all the coils when the first one fails in order to prevent return trips to the repair shop.
Problems for specific Lexus ES300 years:
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Newest reported 2000 Lexus ES300 problems
Sludge can build up in the engine because Lexus did not recommend frequent enough oil changes. Lexus will sometimes offer a discount on cleaning the engine if necessary. Owners who changed their oil every 3,000 miles did not experience these problems. This sludge build up can lead to excessive oil consumption.