A no start condition may be caused by a failed ignition lock cylinder (the ignition key will not turn). If this occurs the ignition lock cylinder will require replacement.
Car Problem Reports
Isuzu Ascender Ignition Lock Cylinder May Fail (Key Will Not Turn)
Isuzu Ascender Problem
Visitor, 2005 Isuzu Ascender, 87,000 mi
My key got stuck int he ignition after car started. Could not turn off car or pull out key. Had to remove fuse for ignition to turn off car so I can later tow it to mechanic to check out car and fix. Was not able to drive car since it would sometimes turn off when low idling at red light. Hope problem is just ignition lock that needs to be replaced.