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Q:

Howling droan coming from rear each time its driven. on 2010 Mazda Mazda5

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Droaning appears to come from rear,& intensifies with speed.Sounds like rear end diff. is going if it had one.Back tires are 60% with wear showing on insides of both.Could it be the tires?
(1) Answer
Yes; tires with abnormal wear patters can really resonate noise.

Also have a look at the vehicle wheel bearings.