How to fix a problem with this vehicle have a multiple misfire problem? on 1999 Chevrolet Blazer

getting code P0300 already have new plugs and wires. some one told me transmission but I do not agree. I really need to know where to look

3 answers
This ignition system can be scoped, fairly easy, suggest having that done! Now if you are just going to throw parts on it start with a new complete distributor and ignition coil. 'Scanner' will also do misfire test and show which cylinder(s) are affected.
Transmission, NO!!!
may need to change the coil pack out with new one - and make sure plugs have correct gap setting on them - a transmission has nothing to do with a engine misfiring, whole different ballgame - hope this helps
Is this an S-10 or Full-Size? Which engine? DEFINITELY NOT TRANSMISSION!!!!!