A loose or worn gas cap could be cause the Check Engine Light to illuminate.
Problems for specific GMC Savana 2500 years:
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Repairpal verified 2010 GMC Savana 2500 problems
The tail light wiring harness in the cargo area is not protected very well. As a result it may become damaged due to normal wear a tear. This damage can causing some or all of the rear lights to stop working.
The fuel pump may fail causing the engine to stall and not restart.