generally speaking, could a 1 inch carb spacer cause a hesitation on take-off. on 1995 Chevrolet 1500 Pickup

the engine is a 383 chev,mild cam,2500 stall speed conv.,dominator carb, headers.the engine is in a chevy C-10 truck.

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2 answers
It sounds like the accelerator pump in you carb is having issues, as the accelerator pump is responsible for a smooth transition from engine idle and take-off. It might be out of adjustment, needing replacement.
very poss carb exccel pump is bad iside carb