The front end may make a rattle noise over bumps. There may be handling issues, and play in the front wheels on inspection. If there is up and down movement on the front wheels while the lower control arms are being supported, inspect the upper and lower ball joints for excessive play. These are prone to failure from moisture entry and lack of lubrication. The ball joints should be replaced as needed.Google+
Car Problem Reports
Ford E-250 Front End May Make Rattle Noise Over Bumps, Handling Issues
Ford E-250 Problem
Average Mileage: 44,900 mi (40,000 mi - 49,800 mi)
Visitor, 2009 Ford E-250, 40,000 mi
Upper and lower ball joints went bad on driverand passenger sides.This should be a recall from ford.They used inferior parts.
Took it to a repair shop to have ball joints changed did not want ford to put their junk back in.
Visitor, 2010 Ford E-250, 49,800 mi
Bad upper and lower ball joints on both sides.