On higher mileage vehicles, one or more EGR orifice in the intake manifold may plug with sludge. This can cause the engine to misfire when first accelerating because too much exhaust gas is directed into the cylinders where the orifice is not plugged. Cleaning the clogged passages should correct this concern.
Problems for specific Ford F-150 years:
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Most reported 2010 Ford F-150 problems
If a noise from the rear end is heard when going around turns or after driving at highway speed for an extended period, there is an updated differential clutch kit available.
Water leaks that appear at the headliner and rear seat area have been known to be coming from the rear high mount stop light. The gasket that seals the light becomes warped over time and allows water to enter through the stop light into the cab area. A revised stop light is available, but I have found that properly placed caulk or foam tape will work also.