If there is a vibration or noise at highway speed, it could be from the frontdrive shaft and may require replacement of the double cardan joint. A double cardan joint is a type of driveshaft joint that uses two universal joints.
Problems for specific Ford F-150 years:
Car problem reports
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Newest reported 1992 Ford F-150 problems
The engine oil pan gasket can develop a leak. Leaking oil may accumulate on the exhaust system resulting in a burning smell. Replacing the gasket should correct this leak.
The battery light may illuminate on the instrument panel because the alternator wire harness connector is damaged. A new connector kit is available and should be installed to correct this concern.
Tubes for the EGR system (exhaust gas recirculation) can break, causing an exhaust leak and noise under the hood.
If a noise from the rear end is heard when going around turns or after driving at highway speed for an extended period, there is an updated differential clutch kit available.